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| Description: The two forms of pig heart citrate synthase homodimer shown here were determined by crystallographic methods and support the induced fit model of enzyme catalysis. In the absence of CoA-SH the enzyme crystallizes in an “open” form. Citrate binds at the base of large clefts in both catalytic domains of the homodimeric protein. Binding of CoA-SH causes the enzyme to adopt a “closed” conformation, with the clefts essentially filled. Picture Stats: Views: 295 Filesize: 451kB Height: 383 Width: 1000 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34223 |