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| Description: Regulation of the mammalian pyruvate dehydrogenase complex by feedback inhibition and by covalent modification of E1. A kinase and a phosphatase inactivate and activate the first component (E1) of the pyruvate dehydrogenase complex by phosphorylating and dephosphorylating, respectively, three specific serine residues. The active form of the pyruvate dehydrogenase complex is feedback inhibited by acetyl-CoA and NADH. Picture Stats: Views: 285 Filesize: 93.97kB Height: 594 Width: 726 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34233 |