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Two models for enzyme–substrate interaction

Two models for enzyme–substrate interaction
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Description: In this example, the enzyme catalyzes a cleavage reaction.

a. The lock-and-key model. In this early model, the active site of the enzyme fits the substrate as a lock does a key.

b. The induced fit model. In this elaboration of the lock-and-key model, both enzyme and substrate are distorted on binding. The substrate is forced into a conformation approximating the transition state; the enzyme keeps the substrate under strain.

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