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Conformational Selection vs. Induced Fit

Conformational Selection vs. Induced Fit
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Description: Induced fit implies conformational homogeneity in the unbound enzyme, which is then distorted upon substrate binding.

Conformational selection implies that the unbound enzyme is present in multiple conformations; but, the substrate can only bind to unbound enzyme that is in the same conformation as that of the ES complex.

Substrate binding will perturb the conformational equilibrium of the unbound enzyme, driving more E into the ES conformation by Le Chatelier’s principle.

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