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Irreversible inhibition by adduct formation

Irreversible inhibition by adduct formation
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Description: Diisopropyl fluorophosphate (DFP) reacts with a serine group on a protein to form a covalent adduct.

The covalent bond renders the catalytically important serine ineffective in catalysis.

The adduct also may block substrate binding to the active site.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34399
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