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Reaction 4: Cleavage to Two Triose Phosphates

Reaction 4: Cleavage to Two Triose Phosphates
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Description: Fructose-1,6-bisphosphate aldolase, catalyzes the “splitting of sugar” that is connoted by the term glycolysis.

The six-carbon sugar fructose-1,6-bisphosphate is cleaved to give 2 three-carbon intermediates, glyceraldehyde-3-phosphate and dihydroxyacetone phosphate (DHAP).

Aldolase cleaves fructose-1,6-bisphosphate under intracellular conditions, even though the equilibrium lies far toward fructose-1,6-bisphosphate under standard conditions.

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