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| Description: The vitamin is structurally complex, but its conversion to the coenzyme form, thiamine pyrophosphate, or TPP, involves simply an ATP-dependent pyrophosphorylation . Thiamine pyrophosphate is the coenzyme for al decarboxylations of a-keto acids. Unlike b-keto acids, a-keto acids cannot stabilize the carbanion transition state that develops during decarboxylation, and they thus require the aid of a cofactor (TPP). The thiazole ring of TPP is the functional part of the coenzyme, allowing it to bind and transfer activated aldehydes. Picture Stats: Views: 297 Filesize: 34.28kB Height: 167 Width: 1014 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34520 |