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| Description: Because the thiazole ring is weakly acidic (pKa ~ 18 for the ring hydrogen), a general base is required in its ionization. As shown in the following diagram, a glutamate carboxyl group in the enzyme deprotonates N-1 of the pyrimidine, which in turn increases the basicity of the amino group, facilitating the deprotonation of C-2 of the thiazole ring to give a dipolar thiazolium carbanion (or ylid). Picture Stats: Views: 266 Filesize: 42.35kB Height: 225 Width: 702 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34521 |