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Thiamine pyrophosphate in the pyruvate decarboxylase reaction

Thiamine pyrophosphate in the pyruvate decarboxylase reaction
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Description: The key reaction (step 2) is attack by the carbanion of TPP on the carbonyl carbon of pyruvate and is followed by nonoxidative decarboxylation of the coenzyme-bound pyruvate to give another carbanion (step 3), which is resonance-stabilized.

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