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| Description: Cytochromes P450 are involved in hydroxylating a large variety of compounds. These reactions include the hydroxylations in steroid hormone biosynthesis and the synthesis of hydroxylated fatty acids and fatty acid epoxides. In addition, cytochromes P450 act upon thousands of xenobiotics. Hydroxylation of foreign substances usually increases their solubility and is an important step in their detoxification, or metabolism and excretion. However, some of these reactions result in activation of potentially carcinogenic substances to more reactive species, as shown for aflatoxin B1 which is converted to more reactive species either by hydroxylation or epoxidation. Picture Stats: Views: 118 Filesize: 60.92kB Height: 691 Width: 293 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34602 |