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| Description: Hormonal activation of a b–adrenergic G-protein coupled receptor on the plasma membrane leads to elevation of cAMP levels, which in turn, activates protein kinase A (PKA). PKA phosphorylates perilipin (PL) and HSL. 1. CGI-58 dissociates from phosphorylated-PL, and binds ATGL . 2. Phosphorylated HSL is recruited to the lipid droplet and activated by phosphorylated-PL. 3. Phosphorylated-PL also recruits the ATGL/CGI-58 complex to the lipid droplet, activating this lipase. 4. Activated ATGL hydrolyzes TG to activated HSL hydrolyzes DG to cytoplasmic MGL hydrolyzes MG to free glycerol + FFA. Picture Stats: Views: 228 Filesize: 64.56kB Height: 412 Width: 569 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34620 |