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Mechanism of acyl-CoA synthetase reactions

Mechanism of acyl-CoA synthetase reactions
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Description: The figure shows reversible formation of the activated fatty acyl adenylate, nucleophilic attack by the thiol sulfur of CoA-SH on the activated carboxyl group, and the quasi-irreversible pyrophosphatase reaction, which draws the overall reaction toward fatty acyl-CoA.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34623
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