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Reaction 1: The Initial Dehydrogenation

Reaction 1: The Initial Dehydrogenation
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Description: The first reaction is catalyzed by an acyl-CoA dehydrogenase, which catalyzes the removal of two hydrogen atoms from the a- and b-carbons to give a trans a,b-unsaturated acyl CoA (trans-D2-enoyl-CoA) as the product.

The pro-R hydrogen on the b-carbon is then transferred as a hydride equivalent to FAD to give the trans double bond and enzyme-bound FADH2.

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