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| Description: The rate-limiting enzyme, acetyl-CoA carboxylase (ACC), is controlled by both allosteric (citrate and long-chain fatty acids) and covalent modification mechanisms. Phosphorylation by AMP-activated protein kinase (AMPK) or cyclic AMP–dependent protein kinase (PKA) inactivates ACC. Insulin stimulates fatty acid synthesis by increasing glucose uptake and increasing flux through pyruvate dehydrogenase to produce acetyl-CoA. The dephosphorylated form of PDH is the enzymatically active form. Picture Stats: Views: 314 Filesize: 142.12kB Height: 933 Width: 537 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34646 |