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Glycerolipid/free fatty acid cycle and glyceroneogenesis

Glycerolipid/free fatty acid cycle and glyceroneogenesis
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Description:
Mammals hydrolyze and resynthesize TG in a glycerolipid/free fatty acid (GL/FFA) cycle.

FFA are released from TG by lipases acting on lipid droplets. ATGL, adipose triglyceride lipase; HSL, hormone-sensitive lipase; MGL, monoacylglycerol lipase.

Some of the FFAs are released into the blood for transport and oxidation, but ~75% are re-esterified back to TG.

ATP hydrolysis in this futile cycle is shown in red.

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