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The glutamine synthetase reaction occurs via an acyl phosphate intermediate

The glutamine synthetase reaction occurs via an acyl phosphate intermediate
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Description: ATP phosphorylates the d-carboxylate of glutamate to give a carboxylic-phosphoric acid anhydride (g-glutamyl phosphate), which undergoes nucleophilic attack by the nitrogen of ammonia to give the amide product, glutamine.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34737
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