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| Description: Ubiquitin is a small (76-residue) protein expressed in all eukaryotic cells—it derives its name from its widespread (ubiquitous) distribution. Ubiquitin is covalently conjugated to specific cellular proteins in an ATP-dependent reaction, which condenses the terminal carboxyl group of ubiquitin with lysine amino groups on target proteins. In the first reaction, catalyzed by the ubiquitin-activating enzyme E1, a thioester is formed between the C-terminal Gly residue of ubiquitin and an internal Cys residue of E1 in a two-step process. Formation of this high-energy covalent linkage is driven by ATP hydrolysis, via a ubiquitin-adenylate intermediate. Picture Stats: Views: 224 Filesize: 129.77kB Height: 430 Width: 362 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34743 |