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Porphyrin biosynthesis

Porphyrin biosynthesis
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Description: 1. Formation of a pyrrole ring.
2. Condensation of four pyrrole moieties, giving a cyclic tetrapyrrole.
3. Side chain modifications and ring oxidations.

Porphyrias involve abnormal accumulations of heme precursors, either from overproduction of the unnatural type I porphyrins or from abnormally high flux through d-ALA synthetase.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34796
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