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Attachment of gene clusters to the nuclear matrix

Attachment of gene clusters to the nuclear matrix
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Description: A map of the repeating histone gene cluster in Drosophila, where each white arrow is a histone gene (arrowheads indicate direction of transcription).

If Drosophila nuclei are extracted with lithium diiodosalicylate, to remove proteins gently, and are then digested with a collection of the restriction endonucleases shown, only the 657-bp HindI-EcoRI DNA fragments are left attached to the matrix.

The interpretation is that the gene clusters exist in individual loops, the bases of which are tied to the matrix.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34919
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