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| Description: The enzyme breaks one strand and immobilizes the 5’ end by a covalent bond between the DNA phosphate and a tyrosine residue (in E. coli topoisomerase I). Rotation of the 3’ end is followed by resealing. The linking number is increased by 1 in the example shown (an underwound DNA). Action of a type I topoisomerase on overwound DNA would decrease the linking number, by essentially the same mechanism. Picture Stats: Views: 256 Filesize: 74.6kB Height: 264 Width: 384 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34959 |