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Crystal structure of human topoisomerase I in complex with a 22-bp DNA duplex

Crystal structure of human topoisomerase I in complex with a 22-bp DNA duplex
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Description: a) The DNA strand nicked by the enzyme is shown in magenta upstream of the cleavage site and in pink downstream, and the intact strand is blue.

The protein wraps completely around the DNA, contacting 4 bp upstream and 6 bp downstream of the cleavage site.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=34961
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