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| Description: Upper left, signal sequence of Hsp70-bound protein inserts into import receptor of the TOM complex (TOM20) in the outer membrane. Hsp70 dissociation is coupled to ATP hydrolysis. Insertion of the protein into the outer membrane (via TOM22) puts signal sequence in position to interact with TIM complex (TIM23) in the inner membrane. Potential across the inner membrane drives protein into intermembrane space. Signal sequence is cleaved off by MPP. Mitochondrial Hsp70 binds to protein in the matrix and uses the energy of ATP hydrolysis to pull the rest of the protein through. Picture Stats: Views: 359 Filesize: 67.19kB Height: 362 Width: 295 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=35107 |