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| Description: a. Activation. Mediator has three distinct structural domains—head, tail, and middle. The tail domain interacts with transcriptional activators (ACT, in red) and links Mediator with RNA polymerase. b. Repression. The four-subunit complex containing Srb8, Srb9, Srb10, and Srb11, when bound to Mediator, prevents its interaction with RNA polymerase II and the basal transcription machinery. Picture Stats: Views: 448 Filesize: 72.94kB Height: 336 Width: 262 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=35139 |