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| Description: (A) A naked strand of DNA is approximately 2 nm in diameter. (B) Histones, which are octameric proteins depicted here as a roughly cylindrical protein, have positive charges distributed on the outer surface to interact with the negatively-charged DNA backbone. (C) Even the organization afforded by histone binding can leave an unmanageable tangle of DNA, especially with longer eukaryotic genomes, and therefore the histone-bound DNA is packaged into the “30-nm strand”. This is held together, in part, by histone interactions. (D) The 30-nm fibers are looped into 700-nm fibers, which are themselves formed into the typical eukaryotic chromosome (E).
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