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Histology of Bone

Histology of Bone
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Description: Bone contains 4 types of cells:

Osteoprogenitor cells (bone stem cells able to differentiate into the other types of cells)
Osteoblasts (bone-building cells that secrete matrix)
Osteocytes (mature bone cells)
Osteoclasts (remodel bones and cause them to release calcium)


A long bone consists of several parts:

Diaphysis (bone shaft)
2 epiphyses (both ends of the bone at the joints)
2 metaphyses (region between diaphysis and epiphysis)
Articular cartilage covering both epiphyses
Periosteum (connective tissue surrounding the diaphysis)
Medullary cavity (hollow space within diaphysis)
Endosteum (thin membrane lining the medulary cavity)




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