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| Description: (a) Transient pairing of X chromosomes may be required for initiating X-inactivation. (b) Deleting the Tsix gene of the Xic locus prevents X–X pairing and leads to chaotic X-inactivation. (c) Blocking X–X pairing by addition of Xic-containing transgenes blocks X–X pairing and prevents X-inactivation.
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