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| Description: The Rb protein inhibits the function of a regulatory transcription factor called E2F that turns on genes that cause a cell to divide. When cells are supposed to divide, Rb is phosphorylated by cyclin-dependent protein kinases, which allows E2F to function. If Rb protein is not made or is not functional because of a mutation, E2F will always be active, and the cell will be stimulated to divide uncontrollably.
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