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| Description: (a) A double-stranded DNA break at a chromosome break point in region H leads to terminal deletion of the acentric fragment. (b) Terminal deletion of chromosome 5 in cri-du-chat syndrome(a) A double-stranded DNA break at a chromosome break point in region H leads to terminal deletion of the acentric fragment. (b) Terminal deletion of chromosome 5 in cri-du-chat syndrome (a) Loss of terminal fragment Telomere Terminal deletion Chromosome E1 5‘ \ Break p 1 4 1 4 oint . 3 3 P 2 2 ' 11 } Centromere 1.2 1.2 2 2 q 1 3 3 4 4 5 5 2 2 t ’ 2 3 2 3 2 , _ _ 3 3 3 Partial deletion 4 ‘. xchromosome 5_ Telomere (b) Terminal deletion in cri-du-chat syndrome Telomesrge Deletion Wild-type / 2 chromosome ’ i 5 Normal Terminal The acentric fragment Chromosome hdeletlon is lost in subsequent 5 C romsosome cell division. Picture Stats: Views: 94 Filesize: 308.07kB Height: 1511 Width: 1500 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=48857 |