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| Description: SI 3'“ 5"H'l'l‘l'l' 3r Mismatch MutH / cleavage site Repaired mismatch Parental strand 0 MutH binds to hemi- methylated DNA. Here, "M" indicates parental- strand methylation. o MutS binds to a base-pair mismatch and attracts MutL, and the complex contacts MutH. a MutH cleaves the unmethylated (new) DNA strand, generating a single-strand gap. 0 The gap is filled by DNA polymerase activity to repair the mismatch.
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