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| Description: Insulator protein Activator protein ; 7‘ij IGF2 OFF ON ‘ y a ’— Maternal ICR H19 Enhancer chromosome IGF2; Paternal chromosome H19 Enhancer On the maternal chromosome, an enhancer drives expression of H79 and an insulator protein blocks IGF2 expression. On the paternal chromosome, methylation inacti- vates the ICR and blocks H7 9 expres- sion; the enhancer drives IGF2 expres— sion.
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