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| Description: _ _ Cleavage by Cleavage by Pn'm'RNA Drosha Dicer 3’ / \ Lower stem Upper stem Terminal loop (~11 bp) (~22 bp) 0 Lower stem cleavage by/ Drosha WW Lower stem Upper stem Terminal loop (degraded) l—l—l Pre-miRNA 9 Terminal-loop cleavage by Dicer Mm l—T—l l_|_l Upper stem Terminal loop (~22 bp) (degraded) e RISC processing to produce miRNA miRNA —-—-———-——-———-—-—-—-
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