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| Description: (a) Forward genetics o Mutagenize 8 Identify Ultrabithorax flies and screen gene W for aberrant sequence. —— ‘ , phenotypes. , 4, TTT GAA CAG ace 9 Analyze , ., «g Q ,1 § We sec TTT TAT /‘ _» molecular ) K W function. Wild type Ultrabithorax mutant Wild t e Hox 10 mutant (b) Reverse genetics yp Hoxa10 d . 0 '50|ate_m9use m 9 Generate m 9 ' 6'1“” 99"“"“"""° W mutant W "mam Drosophila AA allele. phenotype. Lumbar Ultrabithorax“ CTG AGC AAG ccc If —-> cm AGC EKG ccc If gene- m G—AC ATG GCT TAG
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