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Regulation of intracellular pH (pHi)

Regulation of intracellular pH (pHi)
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Description: Regulation occurs when acid loaders decrease the p H in the body. Hydrogen moves into the cells and hydroxide and bicarbonate moves out, all as hydrogen is metabolized. From there a chloride bicarbonate exchanger pushes bicarbonate out and pulls chloride into the cells. Then a sodium bicarbonate cotransporter, 1 to 3 stoichiometry, pulls out both sodium and bicarbonate.

Regulation can also occur when acid extruders raise the p H in the body. Hydrogen is pushed out of the cells via a v type hydrogen pump. Then a sodium hydrogen exchanger pulls sodium in and pushes hydrogen out of the cells. Then a sodium driven chloride bicarbonate exchanger pulls in bicarbonate and sodium and pushes out chloride. Finally, a sodium bicarbonate cotransporter, 1 to 2 stoichiometry, pulls in both sodium and bicarbonate.

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Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=49808
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