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| Description: Effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on bicarbonate secretion by gastric cells. NSAIDs, especially those of the first generation such as aspirin and ibuprofen, have strong effects on hydrogen ion pumps. NSAIDs inhibit the Na+–H+ exchanger (antiport) and thereby decrease intracellular pH. They also inhibit the chloride–bicarbonate (Cl––HCO3–) antiport in gastric epithelial cells, resulting in decreased bicarbonate secretion into the layer of mucus that normally protects the stomach lining from digestion by gastric acid. The first generation, and to a lesser extent the second generation, NSAIDs can cause erosive gastritis and ulcers by these mechanisms. At the top of the diagram is the mucus membrane. The p h is 7.0. Below it, are cells in which chloride is pulled in and bicarbonate is pushed out at the top. At the bottom of 1 cell, chloride is pushed out and sodium carbonate is pulled in. At the bottom of a second cell, hydrogen is pushed out and sodium is pulled in. Between the mucosal cells and the mucus membrane, bicarbonate and hydrogen, which has a p h of 2.0, form C O 2, which passes through the membrane. All other exchanges and movements are inhibited by n saids. Picture Stats: Views: 28 Filesize: 148.06kB Height: 944 Width: 1146 Source: https://biology-forums.com/index.php?action=gallery;sa=view;id=49809 |