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In 1886, William Bates reported on the discovery of a substance produced by the adrenal gland that turned out to be epinephrine (adrenaline). In 1904, this drug was first artificially synthesized by Friedrich Stolz.
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When blood is exposed to air, it clots. Heparin allows the blood to come in direct contact with air without clotting.
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Cyanide works by making the human body unable to use oxygen.
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Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.
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The first oral chemotherapy drug for colon cancer was approved by FDA in 2001.