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Bisphosphonates were first developed in the nineteenth century. They were first investigated for use in disorders of bone metabolism in the 1960s. They are now used clinically for the treatment of osteoporosis, Paget's disease, bone metastasis, multiple myeloma, and other conditions that feature bone fragility.
More than 150,000 Americans killed by cardiovascular disease are younger than the age of 65 years.
Approximately 15–25% of recognized pregnancies end in miscarriage. However, many miscarriages often occur before a woman even knows she is pregnant.
Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
In most cases, kidneys can recover from almost complete loss of function, such as in acute kidney (renal) failure.