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By definition, when a medication is administered intravenously, its bioavailability is 100%.
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The FDA recognizes 118 routes of administration.
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It is believed that the Incas used anesthesia. Evidence supports the theory that shamans chewed cocoa leaves and drilled holes into the heads of patients (letting evil spirits escape), spitting into the wounds they made. The mixture of cocaine, saliva, and resin numbed the site enough to allow hours of drilling.
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Blood in the urine can be a sign of a kidney stone, glomerulonephritis, or other kidney problems.
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It is widely believed that giving a daily oral dose of aspirin to heart attack patients improves their chances of survival because the aspirin blocks the formation of new blood clots.