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Though Candida and Aspergillus species are the most common fungal pathogens causing invasive fungal disease in the immunocompromised, infections due to previously uncommon hyaline and dematiaceous filamentous fungi are occurring more often today. Rare fungal infections, once accurately diagnosed, may require surgical debridement, immunotherapy, and newer antifungals used singly or in combination with older antifungals, on a case-by-case basis.
The immune system needs 9.5 hours of sleep in total darkness to recharge completely.
The first documented use of surgical anesthesia in the United States was in Connecticut in 1844.
The most destructive flu epidemic of all times in recorded history occurred in 1918, with approximately 20 million deaths worldwide.
The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.