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Drug-induced pharmacodynamic effects manifested in older adults include drug-induced renal toxicity, which can be a major factor when these adults are experiencing other kidney problems.
Cocaine was isolated in 1860 and first used as a local anesthetic in 1884. Its first clinical use was by Sigmund Freud to wean a patient from morphine addiction. The fictional character Sherlock Holmes was supposed to be addicted to cocaine by injection.
People with high total cholesterol have about two times the risk for heart disease as people with ideal levels.
The term pharmacology is derived from the Greek words pharmakon("claim, medicine, poison, or remedy") and logos ("study").
Nearly 31 million adults in America have a total cholesterol level that is more than 240 mg per dL.