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The Romans did not use numerals to indicate fractions but instead used words to indicate parts of a whole.
Barbituric acid, the base material of barbiturates, was first synthesized in 1863 by Adolph von Bayer. His company later went on to synthesize aspirin for the first time, and Bayer aspirin is still a popular brand today.
Although the Roman numeral for the number 4 has always been taught to have been "IV," according to historians, the ancient Romans probably used "IIII" most of the time. This is partially backed up by the fact that early grandfather clocks displayed IIII for the number 4 instead of IV. Early clockmakers apparently thought that the IIII balanced out the VIII (used for the number 8) on the clock face and that it just looked better.
On average, someone in the United States has a stroke about every 40 seconds. This is about 795,000 people per year.
More than 2,500 barbiturates have been synthesized. At the height of their popularity, about 50 were marketed for human use.