A 35-year-old female is diagnosed with multiple myeloma. Biopsy ...

[ARLKQ]

A 35-year-old female is diagnosed with multiple myeloma. Biopsy of the tumor reveals Russell bodies, and laboratory testing reveals kidney dysfunction.
 
  Which substance should the nurse monitor as it is accumulating in the patient's body?
  a. Glycogen
  b. Protein
  c. Pigment
  d. Melanin

Question 2

The early dilation (swelling) of the cell's endoplasmic reticulum results in:
 
  a. increased aerobic metabolism.
  b. failure of DNA.
  c. reduced protein synthesis.
  d. increased Na+-K+ pump function.

[kaykay69]

Answer to Question 1

ANS: B
Russell bodies occur due to excess aggregates of protein. Excess glycogen would affect blood glucose. Increased pigment would not lead to kidney dysfunction. Melanin accumulates in epi-thelial cells (keratinocytes) of the skin and retina.

Answer to Question 2

ANS: C
Early dilation of the endoplasmic reticulum causes the ribosomes to detach from the rough endo-plasmic reticulum, reducing protein synthesis. Aerobic metabolism is a normal process and would not lead to swelling. Cellular swelling will not alter cellular DNA. A reduction in the Na+-K+ pump leads to an intracellular accumulation of sodium and calcium and diffusion of potassium out of the cell. Sodium and water can then enter the cell freely, and cellular swelling results.

[ARLKQ]

TYSM

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