A newborn male has been diagnosed with hypospadias following his ...

[abc]

A newborn male has been diagnosed with hypospadias following his postpartum assessment by a pediatrician. Which of the following diagnostics and treatment options is the physician most likely to rule out first?
 
  A)
  Chromosomal studies
  B)
  Circumcision
  C)
  Surgical repair
  D)
  Testosterone supplementation

Question 2

A couple who have three daughters would like to add a son to their family, and they have recently learned that the woman is pregnant.
 
  Which of the following phenomena would most likely be associated with the woman's eventual delivery of a healthy son?
  A)
  The production of dihydrotestosterone (DHT) by the embryo and DHT's differentiation into testosterone
  B)
  Development of testes under the influence of the X chromosome
  C)
  Suppression of female reproductive structures by anti-Mllerian hormone (AMH)
  D)
  Atrophy of the Wolffian ducts during embryonic development

[jliusyl]

Answer to Question 1

Ans:
B

Feedback:

Because the foreskin is often used in surgical repair of hypospadias, circumcision is normally contraindicated. Chromosomal studies are frequently warranted, and surgery is the standard treatment for the repair of the urethra. Testosterone supplementation is often necessary.

Answer to Question 2

Ans:
C

Feedback:

AMH suppresses the development of female genital structures and is a normal aspect of normal sex differentiation. Testosterone is a precursor to DHT rather than vice versa, and testes develop under the influence of the Y chromosome. The Wolffian ducts are a component of male sex differentiation.

[abc]

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[sailorcrescent]

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