The following lab results for a 37-year-old male are shown below:
CSF IgG = 6.0 mg/dL (RI = 2.85.6 mg/dL)
Serum IgG = 54.0 g/L (RI = 6.516.0 g/L)
CSF/serum IgG ratio: (RI = 3.08.7)
Which of the following statements is correct based on the results shown?
A) The patient experienced a decreased intrathecal synthesis of IgG.
B) The results are normal.
C) The blood-brain barrier is intact.
D) The patient experienced an increased plasma IgG crossover from breakdown of the blood-brain barrier.
Question 2
An 18-week-old male develops pneumonia and otitis media due to Streptococcus pneumoniae. Eventually, the child becomes septic with the same organism.
While the peripheral blood demonstrates the presence of lymphocytes, there are no detectable antibody levels of IgG, IgM, IgA, IgD, and IgE. This child may be an example of
A) complement deficiency of the classical pathway. B) severe combined immunodeficiency.
C) DiGeorge syndrome. D) Bruton's agammaglobulinemia.
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