Author Question: What is the most serious clinical consequence of heparin-induced thrombocytopenia? a. Hemorrhage ... (Read 106 times)

crobinson2013 · **on:** Jun 25, 2018

What is the most serious clinical consequence of heparin-induced thrombocytopenia?

a. Hemorrhage
b. Thrombosis
c. Factor XII activation
d. Resistance to aspirin therapy

Question 2

What is believed to be the cause for acute immune thrombocytopenia purpura in children?

a. Development of a platelet-specific autoantibody
b. Development of a white cell autoantibody that cross-reacts with platelet membrane antigens
c. Development of an allogeneic antibody after transfusion of random allogeneic platelets
d. Nonspecific binding of immune complexes to the platelet membrane after a viral illness

nyrave · **Reply #1 on:** Jun 25, 2018

Answer to Question 1

ANS: B
As many as 10 to 30 of patients with heparin-induced thrombocytopenia develop thrombotic problems. Patients who develop heparin-induced thrombocytopenia should be removed from heparin therapy as soon as the diagnosis is made, because continued heparin therapy can lead to significant morbidity and mortality. After discontinuation of heparin the platelet count begins to rise and should return to normal within a few days.

Answer to Question 2

ANS: D
Acute immune thrombocytopenia purpura in children often follows a viral illness. This suggest that some children produce antibodies and immune complexes against viral antigens and that platelet destruction may result from their binding to the platelet membrane.