What coagulation screening test is the most sensitive for ...

[PhilipSeeMore]

What coagulation screening test is the most sensitive for detecting mild liver disease?
 
  a. Fibrinogen
  b. PTT
  c. PT
  d. TT

Question 2

Which of the following proteins is the best test to distinguish moderate to severe liver disease from
 
  a. Factor V concentration
  b. Factor VII concentration
  c. Factor VIII concentration
  d. Factor IX concentration

[vickyvicksss]

Answer to Question 1

ANS: C
Liver disease particularly affects production of the vitamin Kdependent proteins. Because the PT is sensitive to factor VII activity and it (factor VII) has a short half-life of 3 to 5 hours, the PT is the most sensitive for detecting mild liver disease.

Answer to Question 2

ANS: A
Factor V is not vitamin K dependent, but it is produced in the liver so it is decreased in moderate to severe liver disease. Factors VII and IX are both vitamin K dependent, so they are decreased in both liver disease and vitamin K deficiency. Factor VIII is not decreased in either liver disease or vitamin K deficiency; in fact, because it is an acute phase reactant, it may actually be elevated in mild to moderate liver disease.

[PhilipSeeMore]

Thanks for the timely response, appreciate it

[Dominic]

Excellent