What is the basic hemoglobin defect in the thalassemias?
a. One of the globin chains has an amino acid substitution.
b. A structurally normal globin chain is absent or produced at lower levels.
c. Heme is produced at a lower concentration.
d. Iron is not incorporated into the protoporphyrin ring to form heme.
Question 2
Heinz bodies are found when hemoglobin:
a. Precipitates
b. Has higher oxygen affinity
c. Concentration is decreased
d. Forms crystals