« previous next »

Author Question: Interpret the following results: PT: 11.8 sec (RR: 11.2-13.8 sec) INR: 1.07 APTT: 57 sec (RR: ... (Read 63 times)

panfilo

  • Hero Member
  • *****
  • Posts: 572
on: Jun 25, 2018
Interpret the following results:
 
  PT: 11.8 sec (RR: 11.2-13.8 sec)
  INR: 1.07
  APTT: 57 sec (RR: 23-32 sec)
  BT: 12 min
  Ristocetin aggregation: decreased aggregation
 
  Based on this information, from what is the patient most likely suffering?
  a. Hemophilia A
  b. Bernard-Soulier syndrome
  c. DIC
  d. von Willebrand's disease

Question 2

Explain the pathophysiology of the following and why each typically has normal coagulation screening tests.
 
  a. Bernard-Soulier syndrome
  b. Glanzmann's thrombasthenia
  c. -storage pool disease
  d. Gray platelet syndrome
 
  What will be an ideal response?


wshriver

  • Sr. Member
  • ****
  • Posts: 318
Reply #1 on: Jun 25, 2018
Answer to Question 1

Correct Answer: D

Answer to Question 2

Answer regarding pathophysiology: Bernard-Soulier syndrome: defect in glycoprotein Ib/IX
Glanzmann's thrombasthenia: defect in glycoprotein IIb/IIIa
-Storage pool disease: defect in dense granules
Gray platelet syndrome: defect in alpha granules
All four of these disorders are inherited qualitative platelet defects. All have defects in platelet function, not in the synthesis of coagulation factors and/or serine proteases. That is why the clot-based coagulation screening tests are typically normal. They all have prolonged bleeding time because the bleeding time assesses platelet function in vivo and have abnormal platelet aggregation studies.


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
« previous next »
 

Did you know?

Disorders that may affect pharmacodynamics include genetic mutations, malnutrition, thyrotoxicosis, myasthenia gravis, Parkinson's disease, and certain forms of insulin-resistant diabetes mellitus.

Did you know?

Patients who have undergone chemotherapy for the treatment of cancer often complain of a lack of mental focus; memory loss; and a general diminution in abilities such as multitasking, attention span, and general mental agility.

Did you know?

In women, pharmacodynamic differences include increased sensitivity to (and increased effectiveness of) beta-blockers, opioids, selective serotonin reuptake inhibitors, and typical antipsychotics.

Did you know?

Warfarin was developed as a consequence of the study of a strange bleeding disorder that suddenly occurred in cattle on the northern prairies of the United States in the early 1900s.

Did you know?

Medication errors are more common among seriously ill patients than with those with minor conditions.

Crossing Over Results in Genetic Recombination Crossing Over Results in Genetic Recombination
Crossing Over Results in Genetic Recombination p2 Crossing Over Results in Genetic Recombination p2
Pneumothorax. Figure illustrates how puncture of thoracic wall and tearing of pleural membrane allow Pneumothorax. Figure illustrates how puncture of thoracic wall and tearing of pleural membrane allow
Agonists, partial agonists, and antagonists: (a) An agonist results in maximum response. (b) A ... Agonists, partial agonists, and antagonists: (a) An agonist results in maximum response. (b) A ...
If the gauge reading is now much higher than the first test results, then the cause of the low ... If the gauge reading is now much higher than the first test results, then the cause of the low ...
Predictions for the results of mutation of an overlapping and a nonoverlapping genetic code Predictions for the results of mutation of an overlapping and a nonoverlapping genetic code
Video: Facilitated Diffusion - Glucose transport

For a complete list of videos, visit our video library