This topic contains a solution. Click here to go to the answer
« previous next »

Author Question: Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process. ... (Read 34 times)

pragya sharda

  • Hero Member
  • *****
  • Posts: 566
on: Jun 25, 2018
Describe megakaryocyte development and the role of endomitosis and thrombopoietin in this process.
 
  What will be an ideal response?

Question 2

Which of the following best describes the role of platelet factor 4?
 
  a. Stimulates platelet aggregation
  b. Contributes to fibrin formation
  c. Neutralizes heparin
  d. Acts as a mitogenic factor


Related Topics

Need homework help now?

Ask unlimited questions for free

Ask a Question
Marked as best answer by a Subject Expert

medine

  • Sr. Member
  • ****
  • Posts: 344
Reply #1 on: Jun 25, 2018
Answer to Question 1

Answer: Platelets develop from megakaryocytes. Megakaryocyte maturation is produced through endomitosis, which is different from mitosis because telophase is missing. As a result, nuclear duplication occurs without nuclear or cytoplasmic division. The resulting maturing cells are larger than in the previous stage. MK1 is smaller than MK2, which is smaller than MK3, which is smaller than MK4. The stages are very large (can reach up to 150 mcM), and can be easily spotted under low power when examining bone marrow specimens. These platelets respond to changes in thrombopoietin. Thrombopoietin interacts with c-MPL receptor on the megakaryocytes to induce thrombopoiesis and speed up the maturation time of the megakaryocyte. Mature platelets bud off the megakaryocyte and enter the circulation.

Answer to Question 2

Correct Answer: C


pragya sharda

  • Member
  • Posts: 566
Reply 2 on: Jun 25, 2018
Wow, this really help

kjohnson

  • Member
  • Posts: 330
Reply 3 on: Yesterday
:D TYSM

« previous next »
 

Did you know?

People often find it difficult to accept the idea that bacteria can be beneficial and improve health. Lactic acid bacteria are good, and when eaten, these bacteria improve health and increase longevity. These bacteria included in foods such as yogurt.

Did you know?

The word drug comes from the Dutch word droog (meaning "dry"). For centuries, most drugs came from dried plants, hence the name.

Did you know?

There can actually be a 25-hour time difference between certain locations in the world. The International Date Line passes between the islands of Samoa and American Samoa. It is not a straight line, but "zig-zags" around various island chains. Therefore, Samoa and nearby islands have one date, while American Samoa and nearby islands are one day behind. Daylight saving time is used in some islands, but not in others—further shifting the hours out of sync with natural time.

Did you know?

Hyperthyroidism leads to an increased rate of metabolism and affects about 1% of women but only 0.1% of men. For most people, this increased metabolic rate causes the thyroid gland to become enlarged (known as a goiter).

Did you know?

Your chance of developing a kidney stone is 1 in 10. In recent years, approximately 3.7 million people in the United States were diagnosed with a kidney disease.

Growth and Development Growth and Development
Critial thinking and the nursing diagnostic process Critial thinking and the nursing diagnostic process
Measuring Social Development Measuring Social Development
Bone’s Role in Calcium Homeostasis Bone’s Role in Calcium Homeostasis
For a particular process that is carried out at constant pressure, q = 145 kJ and w = -35 kJ. ... For a particular process that is carried out at constant pressure, q = 145 kJ and w = -35 kJ. ...
Direct Development vs. Incomplete Metamorphosis Direct Development vs. Incomplete Metamorphosis
Video: Renin/Angiotensin (water gain from urine & Na ion and water reabsorption)

For a complete list of videos, visit our video library