A diagnosis of CLL requires morphologic and phenotypic findings of which of the following?
a. Variable absolute lymphocyte counts with few prolymphocytes and CD38+
b. Sustained absolute lymphocyte counts with mature lymphocytes, few prolymphocytes, smudge cells, CD20+, and ZAP-70+
c. Marked absolute lymphocytosis, anemia, and thrombocytopenia; prolymphocytes less than 10
d. Sustained absolute lymphocyte counts; mature lymphocytes; CD3, CD2+, CD4, CD8, CD7+, CD16+, CD56+/CD57
Question 2
A lymph node biopsy from a patient with lymphadenopathy is performed. Which of the following findings would support the diagnosis of a reactive proliferation rather than a malignant lymphoma?
a. A mixed population of cells varying in size, shape, and color
b. Clonality
c. Presence of large, bizarre cells
d. Mitotic activity
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