Which of the following disorders is associated with a ...

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Which of the following disorders is associated with a lymphocytosis?
 
  a. X-linked immunodeficiency syndrome
  b. AIDS
  c. Whooping cough
  d. SCID

Question 2

Correlate each disorder with the following: (1) population (s) most affected by it, (2) whether it produces a lymphocytosis or lymphocytopenia, (3) morphology associated with it, and (4) pathophysiology of the infection.
 
  Infectious mononucleosis
  1. Children, teenagers, adults
  2. Lymphocytosis
  3. Activated lymphocytes: oval nucleus, abundant cytoplasm, basophilic rim, loss of contact inhibition
  4. Lymphocytes are infected with EBV.
  Whooping cough
  5. Children
  6. Lymphocytosis
  7. Lymphocytes with clumped chromatin and indistinct nucleoli

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Answer to Question 1

Correct Answer: C

Answer to Question 2

Infectious mononucleosis
1. Children, teenagers, adults
2. Lymphocytosis
3. Activated lymphocytes: oval nucleus, abundant cytoplasm, basophilic rim, loss of contact inhibition
4. Lymphocytes are infected with EBV.
Whooping cough
5. Children
6. Lymphocytosis
7. Lymphocytes with clumped chromatin and indistinct nucleoli8. Pertussis toxin causes migration of lymphocytes from lymphatic system to the blood and blocks their return to the lymphatic system.
Toxoplasmosis
9. Growing fetus, pregnant mother
10. Lymphocytosis
11. Lymphocytes resemble lymphoblasts or lymphoma cells.
12. Toxoplasma gondii causes follicular hyperplasia that spills over into the blood.
CMV infection
13. Transplant patients, immunocompromised patients
14. Lymphocytosis
15. Reactive lymphocytes
16. CMV infects neutrophils and suppresses cell-mediated immunity.